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董四君

  • 个人简介
  • 科研领域
  • 代表性论文

董四君:中共党员,农学博士,教授,博士生导师,中科院“百人计划”入选者,河北大学高层次拔尖引进人才

通讯地址:河北省保定市五四东路180号,河北大学生命科学学院

邮编071000

Email: sjdong@hbu.edu.cn

网址

专业、学位和授予单位

2001.04-2005.04,生物工程专业,博士学位,东京农工大学;

1998.04-2001.03,生物系统学,  硕士学位,日本筑波大学;

1986.09-1990.07,动物遗传与育种专业,学士学位,中国农业大学

学术任职:厦门大学客座教授,厦门市室内空气与健康重点实验室主任,民盟福建省生态环境委员会副主任,厦门市重点引进人才,城市环境质量与健康效应学科带头人;担任Journal of Environmental HazardsJournal of Environmental Analytical Chemistry,《生态毒理学报》编委,ACS NanoJournal of the American Chemical Society等国际著名学术榜刊物的稿件评审员。

科研工作经历2005.05-2007.03在日本产业技术综合研究所从事博士后研究;2007.04-2009.05任东京女子医科大学国际综合医学研究所研究员;2009年入选中科院“百人计划”;2009.06-2019.12任中国科学院城市环境研究所研究员,2014年获得中国科学院BHPB导师科研奖;2020.01-今任河北大学生命科学学院教授。

主要研究方向

分子生物化学;环境暴露健康效应;天然活性物质分离及健康干预。

包括环境化学污染物诱发疾病发生发展过程中的毒性效应与机理;天然产物提取物对机体健康的干预及在环境预防医学中的应用;在基于代谢组学和/或分子生物学水平上研究暴露标志物和健康效应生物标志物指标体系、评价技术和方法,并利用细胞模型进行验证;在细胞和机体水平上,评估化学污染物暴露对机体的健康危害并为相关疾病的诊断和治疗提供参考。

主要承担科研项目:

1. 科技部重点专项,基于组学技术的新兴污染物近海生态环境效应研究,项目负责人,批准号:2018YFE0103300,2019-2022

2. 国家自然科学基金,双酚A暴露经由雌激素受体影响谷氨酸能神经网络发育及功能的分子机制,项目负责人,批准号:21777158,2018-2021;

3. 国家自然科学基金,从胰岛素信号转导通路探讨BPA促进动脉粥样硬化的作用机制,项目负责人,批准号:21477124,2015-2018;

4. 国家自然科学基金重大项目,中国东部地区典型半挥发持久性有机污染物的来源、归趋、人群暴露及健康风险,主要参与人,2014-2018;

5. 国家自然科学基金,结合多种模型系统研究全氟辛烷磺酸的心脏发育毒性,项目负责人,批准号:21277137,2013-2015;

6. 福建省中科院STS计划配套项目计划,肠道微生态精准调控技术研发,项目负责人,2016-2019

7. 中国科学院与日本学术振兴会(JSPS)共同研究资助项目,基于脂质代谢紊乱和炎症反应探讨大气颗粒物致动脉粥样硬化的分子机制,项目负责人,2018-2021

8. 厦门台港澳和国际科技合作项目,茶叶中环境毒物的检测技术,项目负责人,2016-2018;

9. 环保部公益性行业科研专项,极高持久性和生物蓄积性化学品筛查方法和清单研究,子课题负责人,2013-2015;

10. 厦门市重点实验室专项扶持资金,室内空气与健康,项目负责人,2014-2018;

11. 宁波市自然基金项目,客车车内空气品质评价及污染控制策略探讨,项目负责人,2014-2015;

12. 中科院院地合作(STS)项目,金银花、山苍子有效成分的提取和抗心血管疾病功能食品的产业化,项目负责人,2012-2014

13. 中国科学院国际创新团队项目,城市环境质量与健康效应,课题负责人,2010-2013;

14. 厦门市科技计划重点项目,海洋马达卡鱼作为近海环境激素污染检测活体模型的建立及检测技术研发,项目负责人,2010-2012;

15. 中科院创新工程重要方向项目,环境雌激素与心血管疾病的相关性和分子作用机理,项目负责人,2009-2012;

 

代表论文:

1. Wang H, Chang L, Aguilar JS, Dong S*, Hong Y*. Bisphenol-A exposure induced neurotoxicity in glutamatergic neurons derived from human embryonic stem cells. Environ Int. 2019, 127: 324-332.

2. Ye G, Ding D, Gao H, Chi Y, Chen J, Wu Z, Lin Y, Dong S*. Comprehensive metabolic responses of HepG2 cells to fine particulate matter exposure: Insights from an untargeted metabolomics. Sci Total Environ. 2019, 691:874-884.

3. Wang H, Zhao P, Huang Q, Chi Y, Dong S*, Fan J. Bisphenol-A induces neurodegeneration through disturbance of intracellular calcium homeostasis in human embryonic stem cells-derived cortical neurons. Chemosphere. 2019, 229:618-630.

4. Ye G, Chen G, Gao H, Lin Y, Liao X, Zhang H, Liu X, Chi Y, Huang Q, Zhu H, Fan Y, Dong S* Resveratrol inhibits lipid accumulation in the intestine of atherosclerotic mice and macrophages. J Cell Mol Med. 2019, 23(6):4313-4325.

5. Yulang Chi, Hongou Wang, Yi Lin, Yanyang Lu, Qiansheng Huang, Guozhu Ye, Sijun Dong*. Gut microbiota characterization and lipid metabolism disorder found in PCB77-treated female mice. Toxicology. 2019 May 15;420:11-20.

6. Guozhu Ye ,  Han Gao , Yi Lin ,  Dongxiao Ding ,  Xu Liao , Han ZhangYulang Chi, Sijun Dong*. Peroxisome proliferator-activated receptor A/G reprogrammes metabolism associated with lipid accumulation in macrophages. Metabolomics. 2019 Mar 4;15(3):36.

7. Dongxiao Ding, Guozhu Ye, Yi Lin, Yanyang Lu , Han Zhang , Xu Zhang , Zhenyu Hong, Qiansheng Huang, Yulang Chi, Jinsheng Chen, Sijun Dong*. MicroRNA-26a-CD36 signaling pathway: Pivotal role in lipid accumulation in hepatocytes induced by PM2.5 liposoluble extracts. Environmental Pollution. 2019 May;248:269-278.

8. Guozhu Ye , Han Gao , Zhichao Wang , Yi Lin , Xu Liao , Han ZhangYulang Chi , Huimin ZhuSijun Dong*. PPARα and PPARγ activation attenuates total free fatty acid and triglyceride accumulation in macrophages via the inhibition of Fatp1 expression. Cell Death Disease. 2019 Jan 15;10(2):39.

9. Hongou Wang, Yu Zhu, Yulang Chi, Sijun Dong*. A human embryonic stem cell-based model for benzo[a]pyrene-induced embryotoxicity. Reprod Toxicol. 2019 Apr;85:26-33.

10. Yulang Chi, Yi Lin, Yanyang Lu, Qiansheng Huang, Guozhu Ye, Sijun Dong*. Gut microbiota dysbiosis correlates with a low-dose PCB126-induced dyslipidemia and non-alcoholic fatty liver disease. Science of the Total Environment. 2019 Feb 25;653:274-282.

11. Chen G, Ye G, Zhang X, Liu X, Tu Y, Ye Z, Liu J, Guo Q, Wang Z, Wang L, Dong S*, Fan Y. Metabolomics Reveals Protection of Resveratrol in Diet-Induced Metabolic Risk Factors in Abdominal Muscle. Cell Physiol Biochem. 2018;45(3):1136-1148.

12. Lu YLin Y, Ding D, Su S, Chi Q, Zhang Y, Sun J, Zhang X, Zhu H, Huang Q, Chi Y, Ye G, Tao S, Dong S*. MiR-26a functions as a tumor suppressor in ambient particulate matter-bound metal-triggered lung cancer cell metastasis by targeting LIN28B–IL6–STAT3 axis. Archives of Toxicology. 2018, 92 (3):1023-1035.

13. Huang, Q., Chen, Y., Chen, Q., Zhang, H., Lin, Y., Zhu, M., & Dong S*. Dioxin-like rather than non-dioxin-like PCBs promote the development of endometriosis through stimulation of endocrine-inflammation interactions. Archives of Toxicology, 2017, 91 (4), 1915-1924.

14. Lin Y, Ding D, Huang Q, Liu Q, Lu H, Lu Y, Chi Y, Sun X, Ye G, Zhu H, Wei J, Dong S*.  Downregulation of miR-192 causes hepatic steatosis and lipid accumulation by inducing SREBF1: Novel mechanism for bisphenol A-triggered non-alcoholic fatty liver disease. Biochim Biophys Acta- Molecular and Cell Biology of Lipids. 2017,1862(9):869-882.

15. Huang Q, Chen Y, Lin L, Liu Y, Chi Y, Lin Y, Ye G, Zhu H, Dong S*. Different effects of bisphenol a and its halogenated derivatives on the reproduction and development of Oryzias melastigma under environmentally relevant doses. Sci Total Environ. 2017595:752-758.

16. Huang Q, Chi Y, Deng J, Liu Y, Lu Y, Chen J, Dong S*. Fine particulate matter 2.5 exerted its toxicological effect by regulating a new layer, long non-coding RNA. Scientific Reports, 20177(1): 9392.

17. Zhang Y, Dong S, Wang H, Tao S, Kiyama R. (2016) Biological impact of environmental polycyclic aromatic hydrocarbons (ePAHs) as endocrine disruptors. Environ Pollut. 2016, 213:809-24.

18. Ye T, Kang M, Huang Q, Fang C, Chen Y, Liu L, Dong S*. Accumulation of di(2-ethylhexyl) phthalate causes endocrine-disruptive effects in marine medaka (Oryzias melastigma) embryos. Environ Toxicol. 2016 Jan;31(1):116-27.

19. Huang Q, Chen Y, Chi Y, Lin Y, Zhang H, Fang C, Dong S*. Immunotoxic effects of perfluorooctane sulfonate and di(2-ethylhexyl) phthalate on the marine fish Oryzias melastigma. Fish Shellfish Immunol. 2015, 44 (1), 302-306.

20. Lin Y,Huang Q, Fang C, Wu X, Fan J, Dong S*. The combined effects of DEHP and PCBs on the phospholipase in mice model. Environ Toxicol. 2015, 30(2):197-204.

21. Du M, Fang C, Qiu L, Dong S, Zhang X, Yan C. Diastereoisomer-specific effects of hexabromocyclododecanes on hepatic aryl hydrocarbon receptors and cytochrome P450s in zebrafish (Danio rerio). Chemosphere. 2015; 132:24-31.

22. Sun X, Lin Y, Huang Q, Shi P, Qiu L, Kang M, Chen Y, Fang C, Ye T, Dong S*. Di(2-ethylhexyl) phthalate-induced apoptosis in rat INS-1 cells is dependent on activation of endoplasmic reticulum stress and suppression of antioxidant protection. J Cell Mol Med. 2015; 19(3):581-94.

23. Chao Fang, Bo Ning, Ahmed Bilal Waqar, Manabu Niimi, Shen Lib,Kaneo Satohc, Masashi Shiomid, Ting Ye, Sijun Dong* and Jianglin Fan*. Bisphenol A exposure induces metabolic disorders and enhances atherosclerosis in hyperlipidemic rabbits. Journal of Applied Toxicology. 2015,35(9):1058-1070.

24. Fang C, Ning B, Waqar AB, Niimi M, Li S, Sato Kane, Shiomi M, Ye T, Sun X, Lin Y, Huang Q, Dong S*, Jianglin Fan. Bisphenol A exposure enhances atherosclerosis in WHHL rabbits. PLOS ONE. 2014; 9(10):e110977.

25. Chen Y, Huang Q, Chen Q, Lin Y, Sun X, Zhang H, Zhu M, Dong S*. The inflammation and estrogen metabolism impact of polychlorinated biphenyls on endometrial cancer cells. Toxicol In Vitro. 2014; 29(2):308-313.

26. Ye T, Kang M, Huang Q, Dong S*. Exposure to DEHP and MEHP from hatching to adulthood causes reproductive dysfunction and endocrine disruption in marine medaka (Oryzias melastigma). Aquat Toxicol. 2014,146:115-26.

27. Dong S*, Kang M, Wu X, Ye T. Development of a Promising Fish Model (Oryzias melastigma) for Assessing Multiple Responses to Stresses in the Marine Environment. Biomed Res Int. 2014:563131.

28. Lin Y, Sun X, Qiu L, Wei J, Huang Q, Fang C, Ye T, Kang M, Dong S*. Exposure to Bisphenol A Induces Dysfunction of Insulin Secretion and Apoptosis through the Damage of Mitochondria in Rat Insulinoma (INS-1) Cells. CELL DEATH & DISEASE. 2013, 4, e460.

29. Dong S, Furutani Y, Kimura S, Zhu Y, Kawabata K, Furutani M, Nishikawa T, Tanaka T, Masaki T, Matsuoka R, Kiyama R. Brefeldin A is an estrogenic, Erk1/2-activating component in the extract of Agaricus blazei mycelia. J Agric Food Chem. 2013, 61, 128-136.

30. Shen H, Xu W, Zhang J, Chen M, Martin FL, Xia Y, Liu L, Dong S, Zhu YG. Urinary metabolic biomarkers link oxidative stress indicators associated with general arsenic exposure to male infertility in a han chinese population. Environ Sci Technol. 2013; 47(15): 8843-8851.

31. Fang C, Wu X, Huang Q, Liao Y, Liu L, Qiu L, Shen H, Dong S*. Embryonic exposure to PFOS induced immunosuppression in the fish larvae of marine medaka. Ecotoxicology and Environmental Safety. 2013, 92:104-11.

32. Wang J, Dong S*. ICAM-1 and IL-8 are expressed by DEHP and suppressed by curcumin through ERK and p38 MAPK in human umbilical vein endothelial cells. Inflammation. 2012, 35(3):859-70.

33. Dong SDong S, Furutani Y, Suto Y, Furutani M, Zhu Y, Yoneyama M, Kato T, Itabe H, Nishikawa T, Tomimatsu H, Tanaka T, Kasanuki H, Masaki T, Kiyama R, Matsuoka R. Estrogen-like activity and dual roles in cell signaling of an Agaricus blazei Murrill mycelia-dikaryon extract. Microbiol Res. 2012, 167(4):231-7.

34. Zhang J, Liu F, Chen R, Feng T, Dong S, Shen H. Levels of polychlorinated biphenyls and organochlorine pesticides in edible shellfish from Xiamen (China) and estimation of human dietary intake. Food Chem Toxicol. 2012, 50(12):4285-91.

35. Xu W, Bao H, Liu F, Liu L, Zhu YG, She J, Dong S, Cai M, Li L, Li C, Shen H. Environmental exposure to arsenic may reduce human semen quality: associations derived from a Chinese cross-sectional studyEnviron Health. 2012, 9;11:46.

36. Huang Q, Dong S*, Fang C, Wu X, Ye T, Lin Y. Deep sequencing-based transcriptome profiling analysis of Oryzias melastigma exposed to PFOS. Aquat Toxicol. 2012, 120-121:54-8.

37. Tian M, Peng S, Martin FL, Zhang J, Liu L, Wang Z, Dong S, Shen H. Perfluorooctanoic acid induces gene promoter hypermethylation of glutathione-S-transferase Pi in human liver L02 cells. Toxicology. 2012, 296(1-3):48-55.

38. Wu X, Huang Q, Fang C, Ye T, Qiu L, Dong S*. PFOS induced precocious hatching of Oryzias melastigma--from molecular level to individual level. Chemosphere. 2012, 87(7):703-8.

39. Fang C, Wu X, Huang Q, Liao Y, Liu L, Qiu L, Shen H, Dong S*. PFOS elicits transcriptional responses of the ER, AHR and PPAR pathways in Oryzias melastigma in a stage-specific manner. Aquat Toxicol. 2012, 106-107:9-19.

40. Dong S, Terasaka S, Kiyama R. Bisphenol A induces a rapid activation of Erk1/2 through GPR30 in human breast cancer cells. Environ Pollut. 2011, 159(1):212-8.

41. Huang Q, Fang C, Wu X, Fan J, Dong S*. Perfluorooctane sulfonate impairs the cardiac development of a marine medaka (Oryzias melastigma). Aquat Toxicol. 2011, 105(1-2):71-7.

42. Ying S, Dong S, Kawada A, Kojima T, Chavanas S, Mechin MC, Adoue V, Serre G, Simon M, Takahara H. Transcriptional Regulation of Peptidylargine Deiminase Expression in Human Keratinocytes. J Dermatol Sci. 2009. 53(1):2-9.

43. Dong S, Kiyama R. Characterization of Estrogenic Activity of Ginsenosides in MCF-7 Cells using a Customized DNA Microarray. Food Chem. 2009. 113: 672-678.

44. Zhou Y, Kogiso M, Asakawa M, Dong S, Kiyama R, Shimizu T. Antimicrobial Nanotubes as Delivery Vehicles Consisting of Ag-Embedded Peptidic Lipid-Bilayer Membranes. Adv. Mater. 2009. 21, 1-4.

45. Dong S, Ying S, Kojima T, Shiraiwa M, Mechin MC, et. al.  Crucial Role of MZF1 and Sp1 for the transcriptional regulation of the Peptidylarginine Deiminase Type I Gene (PADI1) in Human Keratinocytes. Journal of Investigative Dermatology 2008.128(3): 549-557.

46. Adoue V, Chavanas S, Coudane F, Méchin MC, Caubet C, Ying S, Dong S, Duplan H, Charveron M, Takahara H, Serre G, Simon M. Long-Range Enhancer Differentially Regulated by c-Jun and JunD Controls Peptidylarginine Deiminase-3 Gene in Keratinocytes. J Mol Biol.  2008. 384(5):1048-1057.

47. Dong S, Inoue A, Zhu Y, Tanji M, Kiyama R. Activation of rapid signaling pathways and the subsequent transcriptional regulation for the proliferation of breast cancer MCF-7 cells by the treatment with an extract of glycyrrhiza glabra root. Food and Chemical Toxicology 2007. 45: 2470-2478.

48. Dong S, Zhang Z, Takahara H. Estrogen-enhanced PADI4 expression in MCF-7 cells mediated by ER-promoted transfactors AP-1, NF-Y and SP1. Molecular Endocrinology. 2007. 21: 1617-1629 .

49. Dong S, Kanno T, Yamaki A, Kojima T, Shirawa M, et. al. NF-Y and Sp1/Sp3 are involved in the transcriptional regulation of the peptidylarginine deiminase type III gene (PADI3) in human keratinocytes. Biochemical Journal. 2006.397(3):449-459.

50. Dong S, Kojima T, Shiraiwa M, Mechin MC, Chavanas S, Serre G, Simon M, Kawada A, Kawada A, and Takahara H. Regulation of the expression of peptidylarginine deiminase type II gene (PADI2) in human keratinocytes involves Sp1 and Sp3 transcription factors. Journal of Investigative Dermatology 2005. 124(5):1026-1033.

 

中文期刊论文:

1. 王泓鸥,董四君*,肠道微生物受环境污染物的影响及其对宿主疾病的调控作用. 生态毒理学报. 201712( 3) : 110-119.

2. 叶婷,康美,黄乾生,方超,陈亚檞,董四君*, 邻苯二甲酸二(2-乙基己)酯和邻苯二甲酸单乙基己基酯对幼年期及青年期海洋青鳉(Oryzias melastigma)的内分泌干扰效应环境化学. 2014, 4(33): 543-550.

3. 孙霞,林怡,董四君* 邻苯二甲酸二(2-乙基)己酯暴露与糖代谢紊乱相关性的研究进展生态毒理学报. 2014, 3(9): 413-420.

4. 方超,黄乾生,董四君* 双酚A和心血管疾病相关性的研究进展环境与健康杂志. 2014, 31: 556-559.   

5. 方超,宁博,范江霖,董四君* 双酚A(BPA)暴露对WHHL家兔糖类和脂类代谢的影响生态毒理学报.  2015, 10(1): 241-251.

6. 黄乾生,陈亚檞,方超,康美,董四君* 盐度影响全氟辛烷磺酸对海水青鳉(Oryzias melastigma)的毒性科学通报201358 : 151-157.    

7. 王佳,孙霞,董四君* 邻苯二甲酸二乙基己酯(DEHP)THP-1细胞IL-1βMMP-8表达及ROS的影响生态毒理学报. 20138 : 350-356.  

8. 叶婷,康美,黄乾生,董四君* 邻苯二甲酸二(2-乙基己)(DEHP)和邻苯二甲酸单乙基己基酯(MEHP)长期暴露对海洋青鳉(Oryzias melastigma)内分泌干扰效应的评价. 生态毒理学报. 2014, 2(9): 253-260.

9. 黄乾生,陈亚檞,董四君* 多氯联苯PCB31对子宫内膜异位症相关基因的影响.  泉州师范学院学报. 2013,31(6): 1-4.  

10. 王佳,董四君* 邻苯二甲酸二乙基己酯(DEHP)毒理与健康效应研究进展生态毒理学报. 2012,7(1): 25-34.

11. 伍辛泷,黄乾生,方超,董四君* 新兴海洋生态毒理学模式生物——海洋青鳉鱼(Oryzias melastigma). 生态毒理学报. 2012, 7(4): 345-353.

12. 孙霞,林怡,董四君* 低剂量双酚A暴露与代谢综合征相关性的研究进展环境与健康杂志. 2012,29(9): 853-857.

 

获授权专利:

1. MATSUOKA RUMIKO; KIYAMA RYOICHI; DONG SIJUN; Extract useful as health supplement, and for treating diseases associated with estrogen deficiency e.g. arteriosclerosis and hyperlipidemia, obtained by extracting Agaricus blazei mycelium and/or its processed material with solvent专利号: WO2010125891-A1 JP2010275294-A JP2015143236-A JP5768230-B2.

2. DONG S J; KIYAMA R. Evaluating activity of Chinese drug or its active ingredient, by administering Chinese drug or its active ingredient to subject, comparing expression profile of gene e.g. mitochondrial phosphoenolpyruvate carboxykinase 2 in subject. 专利号: JP2007319051-A JP5126644-B2.

3. 『フコース结合タンパク质合成系遗伝子が导入された酵母形质転换体』地神 芳文、千木良 裕子、高 暁冬、董四君; 11/113081(USA)04/23/2005.

4. 叶国注董四君朱慧敏林怡黄乾生池毓烺一种评价溴代阻燃剂生物毒性及其遗传效应的方法, 2020-3-10, 中国, 2016108041121.

5. 叶国注董四君林怡朱慧敏用于评价肠道脂质积累及其干预试剂或试剂盒及应用和检测, 2020-3-17, 中国, 2017108114305.

6. 张子莲,董四君一种含有海洋菌多糖的排毒养生保健食品专利号:ZL 201510527604.6

 

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