闫蕾蕾

闫蕾蕾:男,汉族,讲师。毕业于中国医学科学院&北京协和医学院微生物与生化药学专业,获理学博士学位;美国乔治亚大学药学院及佐治亚州立大学化学系博士后。2013年返校。


闫蕾蕾

详细内容:

 

基本情况简介:闫蕾蕾:男,汉族,讲师。毕业于中国医学科学院&北京协和医学院微生物与生化药学专业,获理学博士学位;美国乔治亚大学药学院及佐治亚州立大学化学系博士后。2013年返校。

 

所授课程:

微生物学

环境生物技术

 

科研兴趣与项目:

偏好表观遗传学领域及特殊生境微生物新代谢产物方面研究。参研NIH Grant R01GM086717NSF Career award (Grant MCB-1149521 to I.I.)Georgia State University start-up funds (I.I.)及河北省科技厅 (20091559)项目若干,主持河北大学自然科学研究计划项目一项。

 

5年论文:

1. Exploration of Cyanine Compounds as Selective Inhibitors of Protein Arginine Methyltransferases: Synthesis and Biological Evaluation. Recently submitted.

2. Yan Leilei, Yan Chunli, Qian Kun, Su Hairui, Kofsky-Wofford Stephanie, Zhao Xinyang, Ivanov Ivaylo, Zheng Yujun. Diamidine Compounds for Selective Inhibition of Protein Arginine Methyltransferase 1. J Med Chem. 2014 Mar 27;57(6):2611-22.

3. Leilei Yan, Chunli Yan, Ivaylo Nikolaev Ivanov, Xinyang Zhao, David W Boykin, Yujun George Zheng. A selective Diamidine Inhibitor of Protein Arginine Methyltransferases. Fourth Southease Enzyme Conference. April 20th. 2013. P78. Atlanta, Gegoria, USA.

4. Xu Jian, Wang AH, Oses-Prieto J, Makhijani K, Katsuno Y, Pei M, Yan Leilei, Zheng YG, Burlingame A, Brückner K, Derynck R., Arginine Methylation Initiates BMP-Induced Smad Signaling. Molecular Cell. 2013 Jul 11;51(1):5-19.

5. Yang Cao, Mi Jiaqi, Feng You, Ngo Liza, Gao Tielong, Yan Leilei, Yujun George Zheng. Labeling lysine acetyltransferase substrates with engineered enzymes and functionalized cofactor surrogates. J Am Chem Soc. 2013 May 29; 135(21):7791-4.

6. Juxian Wang, Limin Chen, Sarmistha Halder Sinha, Zhongjie Liang, Huifang Chai, Sakthivel Muniyan, Yu-Wei Chou, Chao Yang, Leilei Yan, You Feng, Keqin Kathy Li, Ming-Fong Lin, Hualiang Jiang, Yujun George Zheng, Cheng Luo. Pharmacophore-based virtual screening and biological evaluation of small molecule inhibitors for protein arginine methylation. J Med Chem, 2012, 55(18): 7978-87.

7. Lei-Lei Yan, Ning-Ning Han, Yu-Qin Zhang, Li-Yan Yu, Jie Chen, Yu-Zhen Wei, Qiu-Ping Li, Ling Tao, Guang-Hui Zheng, Su-E Yang, Cui-Xia Jiang, Xin-De Zhang, Qi Huang, Xugela Habdin, Qiong-Bo Hu, Zhou Li, Shao-Wei Liu, Zhi-Zhen Zhang, Qi-Yang He, Shu-Yi Si and Cheng-Hang Sun. Antimycin A18 produced by an endophytic Streptomyces albidoflavus isolated from a mangrove plant. J Antibiotics, 2010, 63: 259261.

8. 陶玲,旭格拉•哈布丁,韩宁宁,余生艳,闫蕾蕾,栾迎春,刘少伟,郭琳,蒋忠科,余利岩,孙承航*.红树林植物内生放线菌I07A-01824发酵液中杀线虫活性成分的分离、纯化与鉴定. 中国医药生物技术, 2012,7(1): 5- 8.

9. 闫蕾蕾,韩宁宁,何琪杨,陈杰,阳素娥,刘少伟,陶玲,郭琳,靳婧,余利岩,张玉琴,孙承航*. 新天然来源抗生素-抗霉素A18的抗肿瘤活性及其产生菌I07A-01824的生物学特征.中国抗生素杂志, 2011,36(4): 269- 275, 279.

10. 李舟,郑光辉,闫蕾蕾,张玉琴,余利岩,魏玉珍,李秋萍,姜翠霞,韩宁宁,何琪杨,刘少伟,高红,孙承航*.植物内生阿维链霉菌I06A-01716次生代谢产物的研究.中国抗生素杂志.2010,35(3):175-180..植物内生阿维链霉菌I06A-01716次生代谢产物的研究.中国抗生素杂志.2010, 35(3):175-180.

 

联系方式:

地址:河北大学生命科学学院                         邮编:071000

Email: llhbu@126.com